• 18 to 70 years old,regardless of gender

• Diagnosed Patients with malignant solid tumors confirmed histopathologically (including but not limited to mesothelioma, pancreatic cancer, biliary tract cancer, lung cancer, ovarian cancer, gastric cancer, colorectal cancer, thymus cancer, esophageal cancer, breast cancer, and endometrial cancer, etc.) who fail or cannot tolerate standard treatment or lack effective treatment methods as defined by CSCO and NCCN guidelines

• At least have one evaluable lesion;

• Patients who Can provide tumor tissue samples or tumor samples can be obtained through methods such as tumor biopsy;

• Positive expression of MSLN in tumor cells confirmed by Immunohistochemistry (IHC) or immunocytochemistry (ICC) staining

• Eastern Cooperative Oncology Group (ECOG) performance score at 0 or 1;

• Life expectancy ≥ 3 months.

• The organ function must meet the following requirements:

‣ Hematological functions: Absolute neutrophil count (ANC) ≥ 1.5 × 10\^9/L (Without receiving G-CSF support within 7 days prior to laboratory examination); Absolute Lymphocyte Count (ALC) ≥ 0.5 × 10\^9/L; Hemoglobin (HGB) ≥ 80 g/L (without receiving any blood transfusion or erythropoietin stimulating agent therapy within 7 days before the laboratory examination);Platelet count (PLT) ≥ 75 × 10\^9/L (Without receiving platelet transfusion and TPO within 7 days before the laboratory examination)；

⁃ Hepatic functions: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3.0 × upper limit of normal (ULN)(for patients with primary liver tumors or liver metastases ，AST and ALT≤ 5.0× ULN)；Total bilirubin (TBIL) ≤ 1.5 × ULN(for patients with primary liver tumors or liver metastases，TBIL≤ 3.0× ULN；patients with Gilbert's Syndrome，TBIL≤3×ULN and Direct bilirubin≤ 1.5 × ULN).

⁃ Coagulation functions: Activated partial thromboplastin time (APTT) ≤ 1.5×ULN.

⁃ Renal functions: Serum creatinine (Cr)≤1.5 × ULN; or Creatinine clearance rate (Ccr) ≥ 60 mL/min（Cockcroft-Gault）.

⁃ Cardiac functions: Left ventricular ejection fraction (LVEF) \> 50% (confirmed by ECHO).

⁃ Lung fuction:Pulse oxygen saturation (SpO2) \> 95% at rest without oxygenation

• Women of childbearing potential (WCBP) must have negative results on a serum pregnancy test, and WCBP or Male who have partners of reproductive potential must agree to use effective contraceptive methods to avoid pregnancy throughout the screening and study period until 1 year after the last cell infusion;

⁃ Voluntary signing informed consent form(s) indicating that they are willing to participate in the study and are able to comply with the protocol.